FORMULATION AND EVALUATION OF FLOATING MICROSPHERE OF RANITIDINE HYDROCHLORIDE

Abstract

Ranitidine HCl is H2 receptor antagonist inhibits acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. It competitively inhibits histamine action at all H2 receptors but their main clinical use is as inhibition of gastric acid secretion. It inhibited histamine stimulation and gastrin stimulated acid secretion. The microspheres of each batch were subjected to various physicochemical studies i.e. particle size, bulk density, % yield, % buoyancy, drug entrapment efficiency etc. The compatibility of the drug with selected polymers was determined by FTIR spectrophotometric studies using FTIR Affinity -1. The characteristic peaks of pure drug, ethyl cellulose and chitosan were compared with that obtained with the formulation of all the nine batches. Thin layer chromatography was performed and studied comparative to the pure drug and its micro spherical formulations.