FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM FOR IBUPROFEN

  • Nirja Shri Baba Mastnath Institute of Pharmaceutical Sciences & Research, Asthal Bohar, Rohtak-124001
  • Pawan Jalwal Shri Baba Mastnath Institute of Pharmaceutical Sciences & Research, Asthal Bohar, Rohtak-124001
  • Jyoti Saini Shri Baba Mastnath Institute of Pharmaceutical Sciences & Research, Asthal Bohar, Rohtak-124001
  • Mamta Shri Baba Mastnath Institute of Pharmaceutical Sciences & Research, Asthal Bohar, Rohtak-124001
  • Ritu Department of Pharmacy, Maharishi Dayanand University, Rohtak-124001
Keywords: Transdermal patch, Ibuprofen, prostaglandin synthetase inhibitor, NSAIDs etc

Abstract

In the present study the transdermal patch of Ibuprofen was formulated. . The drug is usually administered as the racemic compound, but preparations containing only the S (þ)-enantiomers (dexibuprofen) are available in some countries. Ibuprofen is usually given as the free acid but various salts, esters, and other complexes are also used. The pKa of ibuprofen is in the range of 4.5–4.6. Ibuprofen is well absorbed throughout the gastrointestinal tract and is therefore suitable as a model drug in relation to study of colon-specific formulations. The elimination half-life of ibuprofen is about 2 hours. Therapeutic concentrations in plasma range from 5 to 50 mg/l.
How to Cite
Nirja, Pawan Jalwal, Jyoti Saini, Mamta, & Ritu. (1). FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM FOR IBUPROFEN. International Journal of Pharma Professional’s Research (IJPPR), 4(2), 794-808. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/131
Issue
Vol 4 No 2 (2013): April Issue-2
Section
Articles

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