RECENT ADVANCES IN COLON TARGETED DRUG DELIVERY SYSTEMS

Abstract

The colon route can be employed for both local and systemic delivery of drugs. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This article, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems. These achieved limited success and had limitations as compared with newer CDDS. Newer platform technologies are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.