PROGRESS IN FLOATING DRUG DELIVERY SYSTEMS: A REVIEW

Abstract

One of the most feasible approaches for achieving a prolonged and predictable drug delivery profiles in the gastrointestinal tract is to control the gastric residence time, using gastro retentive dosage forms that will provide us new and important therapeutic options. This review focus primarily on floating drug delivery systems (FDDS) and to compile the recent literature on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention. FDDS provides local delivery to specific region like stomach and proximal small intestine and it also shows better bioavailability and improved therapeutic activity and substantial benefits to patients.