RECENT ADVANCES ON MUCOADHESIVE DRUG DELIVERY SYSTEM FOR ANTI ULCER DRUG

Abstract

Over the past few decades, mucosal drug delivery has received a great deal of attention. The drug adopted mucoadhesive delivery systems interact with the mucus layer which is covered by mucosal epithelial surface, mucin molecules and increase the residence time of the dosage form at the site of absorption. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. In this regard, this review covers the areas of mechanisms and theories of mucoadhesion, factors influencing the mucoadhesive devices and also various mucoadhesive dosage forms (buccal, nasal, ocular, gastro, vaginal, and rectal).