DESIGN AND CHARACTERIZATION OF SULINDAC MATRIX TABLETS FOR COLON TARGETING

  • Rakesh Kumar Vaish Institute of Pharmaceutical Education and Research, Rohtak
  • Sarita Garg Vaish Institute of Pharmaceutical Education and Research, Rohtak, Haryana
  • Jyoti Kirar Vaish Institute of Pharmaceutical Education and Research, Rohtak, Haryana
  • Sumit Sigroha Department of Pharmaceutical Sciences, MD University, Rohtak
Keywords: Sulindac, Colon, Sustained release, Guar gum, Eudragit RL, Eudragit RS.

Abstract

The present study is the development of colon targeted matrix tablets of the drug Sulindac, a Nsaids of the class of Ibuprofen designed to prolonged the release for sustained effect.Different formulation( F1 TO F9 ) batches were made with the help of different polymers and their different proportions (Guar gum,Eudragit RL,Eudragit RS ) with the help of Wet granulation techniques.The prepared matrix tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, invitro drug release. From this study we concluded that the batch F7 shows good results then the other batches.The batch F7 shows maximum prolong release upto 12 hrs.
How to Cite
Rakesh Kumar, Sarita Garg, Jyoti Kirar, & Sumit Sigroha. (1). DESIGN AND CHARACTERIZATION OF SULINDAC MATRIX TABLETS FOR COLON TARGETING. International Journal of Pharma Professional’s Research (IJPPR), 13(1), 1-5. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/210
Issue
Vol 13 No 1 (2022): January Issue-1
Section
Articles