ANTIBACTERIAL, ANTIOXIDANT, ANTIMICROBIAL AND WOUND HEALING POTENTIAL OF TRITICUM AESTIVUM & TERMINALIA BELLIRICA

Abstract

Objective: To investigate the ethanolic and aqueous extracts of Terminalia bellirica, Triticum Aestivum for potential of antioxidant, antibacterial, antimicrobial and wound healing activity. Methods: The antioxidant, antibacterial, antimicrobial activity of extract was studied against the 8 bacterial and 2 fungal strains using agar cup plate method. Antibacterial activities were evaluated against five microorganisms using agar well diffusion method the effect of 5% and 10% ointments of Terminalia bellirica, Triticum Aestivum ointments were evaluated by incision and excision model in rats. The wound healing activity of 5% & 10% ointment were assessed by the breaking strength, % wound contraction and period of Epithelialization. Results: Antibacterial activities were evaluated against two microorganisms in which T. Billerica; T. Aestivum showed significant activity with a MIC of 1.562 mg/ml, 3.125 mg/ml respectively. The plant extracts of brown raisins T. bellirica, T. Aestivum showed remarkable antioxidant activity. The results showed that both the ointments exhibited significant antimicrobial activity against all the tested microorganisms and have significant wound healing activity as evident from the breaking strength; % wound contraction and period of epithelialization. The topical application of individual and combination of plant extracts on wounds caused significantly faster healing in wound area as compared to the commercial ointment. Conclusions: The present study provides a scientific rationale for the traditional use of these plants in the management of wounds. These results shows that the combination of these plants extracts possess effective wound healing properties due to their antimicrobial and antioxidant activities by possessing the active compounds.