Design & Evaluation of Immediate Release Tablet of Rupatadine Fumrate

  • Syed azeem hyder Teerthanker Mahaveer college of pharmacy,Teerthanker Mahaveeer University Moradabad,[U.P]
  • Shaweta sharma Teerthanker Mahaveer college of pharmacy,Teerthanker Mahaveeer University Moradabad,[U.P]
Keywords: Rupatadine Fumrate,Immediate release

Abstract

The objective of this research was to formulate immediate release tablet of Rupatadine fumarate for rapid action. Direct compression method was adapted to prepare the tablets by using mannitol, microcrystalline cellulose as filler, crospovidone, alginic acid & sodium CMC as super disintegrants in different concentration (2-5%).Total twelve formations and one control tablet were prepared and evaluated for Hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and invitro drug release. The formulations were compared with control formulation for disintegration time and % drug release. It was concluded the immediate release tablet for Rupatadine fumarate can be formulated for emergency treatment of allergic rhinitis. FT-IR studies revealed that there was no physico-chemical interaction between Rupatadine fumarate and other excipients. All formulations are evaluated for pre-compression and post-compression parameters, wetting time, water absorption ratio. The results obtained showed that . The results indicate that the selelected batch of tablet formulation containing crospovidone provides a short DT between 40 to 22 seconds sec with sufficient crushing strength and acceptable friability.
How to Cite
Syed azeem hyder, & Shaweta sharma. (1). Design & Evaluation of Immediate Release Tablet of Rupatadine Fumrate. International Journal of Pharma Professional’s Research (IJPPR), 3(4), 660-668. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/115