SPECTROPHOTOMETRIC ESTIMATION OF ACELOFENAC BY USING DIFFERENT HYDROTROPS

Abstract

Acelofenac is a non-steroidal anti-inflammatory drug(NSAID) that exhibit analgesic,antipretic and anti-inflammatory activities. It is poorly water soluble drug. In the present study, the effect of various hydrotropes such as sodium citrate,sodium Salicylate and pH on the solubility of acelofenac was investigated. The solubility enhancement of acelofenac by the hydrotrope was observed in decreasing order as sodium salicylate>Sodium citrate. The result of solubility studies at different pH indicated that acelofenac was more soluble at alkaline pH than acidic pH. Each solubilized product was characterized by ultraviolet ,infrared, mass spectroscopy, nuclear magnetic resonance techniques.There are about thirty fold increase in solubility of acelofenac by Sodium Salicylate