GASTRO-RETENTIVE BUOYANT FLOATING DRUG DELIVERY SYSTEM: A REVIEW

Abstract

A controlled drug delivery system with prolonged residence time in the stomach is of particular interest for drugs that i) are locally active in the stomach, ii) have an absorption window in the stomach or in the upper small intestine, iii) are unstable in the intestinal or colonic environment, or iv) exhibit low solubility at high pH values. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention.This review covers all the aspects related to gastric retention such as basic GIT ( gastrointestinal tract) physiology,factors affecting gastric retention time. This article also covers recent approaches to gastric retention as well as in vivo-in vitro parameters of stomach specific FDDS.