RECENT RESEARCH AND ROLE OF NANOPARTICLE IN OCCULAR DISEASES TREATMENT

Abstract

In the current review various eye diseases were studied with respect to the nanoparticulate ophthalmic drug delivery system which is one of the most challenging endeavors in the pharmaceutical research. The anatomy, physiology, and biochemistry of the eye render this organ highly impervious to foreign substances. The choice of drug delivery system and route of drug administration is driven by patient acceptability, the properties of the drug access to a disease location, or effectiveness in dealing with the specific disease. Particulate polymeric drug delivery systems include micro and nanoparticles. The upper size limit for microparticles for ophthalmic administration is about 5-10 mm and range of nanoparticles are less than 100nm, so nanoparticulate drug delivery is best suitable approach for the eye targeting and nanoparticle also enhances drug pharmacokinetic properties and also minimize side effect and toxicity of drug. Patents obtained for ocular drug delivery devices/strategies focus about the research in ocular drug delivery.