ALZHEIMER’S - A NEURODEGENERATIVE DISEASE; START TO END

Abstract

Alzheimer’s disease (AD) which is a progressive, irreversible, age-related, neurological and psychiatric disorder characterized by a progressive decline in memory, cognitive performance and loss of acquired skills leading to apraxia, agnosia, anomia and aphasia. The extra cellular accumulation of amyloid beta peptide, Intracellular hyperphosphorylation of Tau-proteins, Inflammatory reactions such as involvement of interleukins (IL-1 beta and TNF-alpha), excitotoxicity, oxidative stress and expression of COX and LOX are involve in the basic pathophysiology of AD. There are some neurotoxic chemicals such as streptozotocin and colchicines which are given intracerebroventricularly in rat’s brain as animal model to induce Alzheimer’s disease.