EVALUATION OF THE ANTIPYRETIC & ANALGESIC ACTIVITY OF AQUEOUS & CHLOROFORM EXTRACT OF PHYLLOSTACHYS BAMBUSOIDES LEAVES

Abstract

The study was conducted to screen the antipyretic activity & analgesic activity of water & chloroform extract of the leaves of Phyllostachys bambusoides. Healthy rats weighing between 120-150 gm were divided into five groups five in each group. The initial temperature of each animal recorded with digital temperature. 15% suspension of Brewer’s yeast in 0.9% saline is prepared .The animals are fevered by injection of 10 ml/kg of Brewer’s yeast suspension subcutaneously in the back below the nape of the neck. The difference in temperature between 0 hr & respective time interval was found out by statistical method. The potency of both extract to bring down the temperature was compared with that of the control group. The extract exhibited marked analgesic effect by reduction of writhing induced acetic acid at a dose of 200 mg/kg orally .The inhibition of writhing was calculated in respective to control (vehicle). The test sample at a dose of 200mg/kg body weight of experimental animals where Diclofenac at a dose of 150 mg/kg body weight was used as a standard drug in this study.