RECENT ADVANCED - SMARTER TECHNIQUES OF ANALYSIS

Abstract

Pharmaceutical analysis has adopted many faster and smarter processes to deals with increasing commercial and social pressure to develop new medicines with reduced costs and improved productivity. These all techniques are nondestructive, rapid, and accurate methods for drugs and dosage forms. A number of new techniques are discussed like NIR, Direct Analysis in Real Time (DART), Deep Raman spectroscopy include probing of the active ingredients in pharmaceutical capsules in a fluorescent shell, study of counterfeit tablets in glass bottle, the detection of powders in opaque plastic containers, and non-invasive detection of herbs in bottle. The techniques are also used for analysis of crude drugs for its active constituents. Ion mobility spectrometry (IMS) is used to separate and identify ionized molecules in the gas phase based on their ion mobility in a carrier buffer gas. A best method for detection of narcotics, abused drugs and other harmful substances in trace quantity also. The other technique Ultra high performance liquid chromatography (UPLC) has advantage of reduced run time, less solvent consumption and increased peak capacities. It used for the quality evaluation of herbs and medicines. DOSY NMR technique gives information of active as well as excipients in form of multivarient fingerprint. Tera hertz pulse technique techniques uses electromagnetic spectrum between microwaves and infrared.