DEVELOPMENT AND IN-VITRO EVALUATION OF BUCCOADHESIVE FORMULATION OF DIMENHYDRINATE TABLET

Abstract

Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Dimenhydrinate is an anti-emetic drug. It was under goes extensive first pass metabolism resulting in an oral bioavailability of 46 % and it shows variable absorption from GIT. Buccal route offers several advantages such as rapid absorption, high plasma concentration level and ease of administration and termination of therapy. The present investigation concerns the development of Buccoadhesive tablets of Dimenhydrinate which were designed to prolong the buccal residence time after oral administration. Buccal tablets of Dimenhydrinate were formulated using four mucoadhesive polymers namely, Carbopol 934 P, HPMC K4M, HPMC K15M and Sodium carboxymethylcellulose carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, Bioadhesive force and in vitro drug release. Formulation of F5 were formulated by using polymers Carbopol 934 P and Sodium carboxymethylcellulose provided controlled release of Dimenhydrinate over period of 8 hrs. The cumulative % of drug release of formulation F5 were 96.67. In-vitro releases of F1 to F9 were found to be diffusion controlled and followed zero order kinetics. The stability studies showed that there was no significant change in adhesive strength, in-vitro release when stored at room temperature, 40oC, 2-8 oC for a period of 30 days. Formulation of F5 which were formulated by using polymers Carbopol 934 P and Sodium corboxymethylcellulose were established to be the optimum formulation with optimum bioadhesive force, swelling index & desired in-vitro drug release. Further investigations are needed to confirm the in-vivo efficiency, long term stability studies are needed to stabilize the controlled released (F5) formulations