EVALUATION OF SYNERGISTIC EFFECT OF METHANOLIC LEAVES EXTRACT OF HYGROPHILA DIFFORMIS ON PROLONGATION OF SLEEPING TIME ALONG WITH THIOPENTONE SOD. - A COMPARATIVE STUDY WITH DIAZEPAM.

Abstract

The objective of the study was to evaluate the synergistic effect of methanolic extract of leaves of H.difformis on prolongation of sleeping time along with thiopentone sod. as compare with diazepam. The material was dried in shade, they were powdered and extracted with methanol. Preliminary phytochemical test were done. The methanolic extract showed presence of phenolic compounds, flavonoids, tannins, steroids & also alkaloids. . The methanol extract at an IP dose of 200 mg/kg and 400mg/kg exhibited a significant effect (p<0.01) on thiopentone sod. induce sleeping time, where as 400mg/kg dose of H.difformis showed greater effect which is comparable with diazepam (4mg/kg). Our findings suggested that methanolic leave extract of H.difformis possessed hypnotic effect in the dose dependent manner