Utilization of ionotropic gelation method for targeting an Anti-viral nanoparticulate  gel at the corneal surface for management of Varicella zoster viral infection

Bhanoo Pratap Singh; Shipra; Vineet; Neha Saini; Mohit Giri

doi:10.69580/IJPPR.15.2.2024.19-31

Bhanoo Pratap Singh Monad University, N.H. 9, Delhi Hapur Road
Shipra Monad College of Pharmacy, Monad University, Hapur
Vineet Monad University, N.H. 9, Delhi Hapur Road
Neha Saini Monad University, N.H. 9, Delhi Hapur Road
Mohit Giri Monad College of Pharmacy, Monad University, Hapur

DOI: https://doi.org/10.69580/IJPPR.15.2.2024.19-31

Abstract

The objective of the present work was to develop
nanoparticulate gel of Acyclovir to enhance its residence time at
ocular surface and release the drug in sustained manner for prolonged
period. Initially, nanoparticles of selected drug was prepared. For
that, Acyclovir and PLGA (100 to 400 mg) was taken in 1:1 ratio.
The prepared nanoparticles were evaluated for entrapment
efficiency, particle size & zeta potential, PDI, surface morphology
and in-vitro drug release. The optimized formulation was then
converted into gel by using Poloxamer 407 and Carbopol 940,
thermo-responsive gelling agents. It was found that prepared
formulation was clear. The pH value of the formulation was found
nearly similar with lacrimal environment. The prepared gel
formulation showed sustained drug release for a period of 12 h. The
formulation was clear with pH value of 7.4. From the stability
studies, it was revealed that optimized nanoparticulate gel
formulation of Acyclovir (ACT) was remained stable at given
conditions of temperature and humidity. Hence the research work, in
reference, comprised of quite novel approaches of investigations.