DEVELOPMENT AND CHARACTERIZATION OF CITICHOLINE LIPOSOMES

Abstract

We developed pH-responsive liposomes containing Citicholine and evaluated their properties both in vitro and in vivo with the aim of constructing an efficient liposome-based systemic drug delivery system. Loading of the drugs into liposomes has proved to be a measure of their utility. If there is poor loading, there is a great loss of the active drug and the use of liposomes as the pharmaceutical vehicle becomes uneconomical. Several methods exist for improved loading of the drugs, including remote (active) loading methods which load drug molecules into preformed liposomes using pH gradients and potential differences across liposomal membranes.