An Overview: Mucoadhesive Nasal In-Situ Gel as Nasal Drug Delivery System

Abstract

In-situ forming polymeric gel formulations are drug delivery systems that are in solution form before administration in the nasal cavity, but once administered, undergo gelation to form a gel enhancing the flexibility of administration. The gel formation depends on factors like temperature modulation, pH change, presence of ions, and ultraviolet irradiation, from which the drug gets released in a sustained and controlled manner. In recent years, the nasal route has been identified as a promising alternative drug delivery route for systemic therapy. Various nasal formulations show less residence time while Mucoadhesive in situ gel formulations have demonstrated an increase in the residence time in the nasal cavity as well enhancement of the permeation characteristics of the drug will reduce the dosage frequency and it enhance patient compliance. With a brief introduction to nasal drug delivery, in this paper, the use of novel mucoadhesive in situ gels for the intranasal delivery of drugs is reviewed along with methods available for evaluating in situ gels.