ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF A MARKETED POLY HERBAL FORMULATION (PHF)

Abstract

The effect of PHF was investigated in experimental models of pain and inflammation. Analgesic activity of PHF (30,100,300, and 500 mg/kg, p.o.) was studied in mice using acetic acid induced writhing, tail immersion method and hot plate method. Anti-inflammatory activity of PHF (30, 100 and 300 mg/kg, p.o.) was studied in rats using carrageenan induced hind paw edema and formalin induced rat paw edema method. PHF (100, 300, and 500 mg/kg) significantly (p0.05) reduced the number of writhing, increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method. PHF (30, 100, and 300mg/kg) significantly (p0.05) inhibited carrageenan induced hind paw edema and formalin induced rat paw edema.