RECENT ADVANCES IN FLOATING DRUG DELIVERY SYSTEM FOR ANTI ULCER DRUG

Abstract

In recent years various scientific and technological advancements have been made for oral drug delivery system. Various approaches have been proposed to increase gastric residence time. It include Floating drug delivery system, Swelling or expanding system, Mucoadhesive system, Magnetic System, Modified shape system, hydrodynamically balanced system etc. Floating drug delivery system is commonly used among these techniques. Floating drug delivery systems are the systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. Floating dosage systems form important technological drug delivery systems with gastric retentive behavior and offer several advantages in drug delivery. Treatment of gastrointestinal disorders such as gastro-esophageal reflux improved drug absorption, because of increased gastric retention time (GRT) and more time spent by the dosage form at its absorption site. Ease of administration and better patient compliance and minimizing the mucosal irritation due to drugs.