IN VITRO RELEASE PROFILE OF EXTENDED RELEASE MATRIX TABLET OF DICLOFENAC SODIUM BASED ON HYDROPHOBIC MATRIX USING ETHYL CELLULOSE POLYMER

Abstract

The anti-inflammatory action effects of Diclofenac sodium are believed to be due to inhibition of both leukocyte migration and enzyme COX (COX1&COX-2) leading to peripheral inhibition of prostaglandin synthesis. Formulation of Diclofenac sodium was formed by different techniques like direct compression and wet granulations having 100 mg strength. Batch M1 was formed by direct compression and batch M3 was formed by wet granulations. Four batches (M3, M4, M5 and M6) were formed to check the effect of different viscosity grade of ethyl cellulose. Four batches (M7, M8, M9 and M10) were formed to check the effect of different fine particle grade of ethyl cellulose. Batches M10 and M11 shows the comparisons on the basis of different concentrations of the binder (Microcrystalline cellulose). Batches M10 and M12 shows the comparisons on the basis of different concentrations of the ethyl cellulose. Batches M13 and M14 shows the comparisons on the basis of different concentrations of the diluents with their elastic and plastic properties. Batches M15 and M16 show the comparisons with batch M10 and M13 using different diluents in double concentrations. The overall studies show that the formulation techniques were shown an effect on extended release dosage forms. The wet granulation technique is the best technique for extended release dosage forms. This technique gives the best evaluation parameters of the tablets. Another studies show that the concentration of binder plays an important role in the release of extended release. When the concentration of the binder is increased, the release of the dosage form will decrease which is necessary for extended release.