ANTIDIABETIC POTENTIAL OF METHNOLIC BARK EXTRACT OF FICUS RELIGIOSA L. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Keywords:
Solid lipid, Ficus religiosa, Blood glucose, Antidiabetic, Streptozotocin
Abstract
Objective: The present study was designed to investigate the hypoglycemic property of a methnolic extract of Ficus religiosa L. which is widely used as a traditional treatment for diabetes mellitus. Materials and methods: The methanolic extract of Ficus religiosa bark administered orally at a dose of 100 mg/kg, for 15 days to streptozotocin–induced diabetic rats. Fasting blood glucose level and change in body weight assessed in methnolic extract treated diabetic rats, were compared with normal animal, diabetic control and standard drug treated mice. Results: The yield of methanolic extract in Ficus religiosa bark was found to be18.17 %. Methanolic extract of Ficus religiosa bark produced a significant reduction in fasting blood glucose level in streptozotocin–induced diabetic rats. Significant differences were also observed in body weight by methnolic extract treated diabetic mice, when compared with diabetic control, normal control and standard drug treated rats. Conclusion: Methnolic extract of Ficus religiosa exhibit significant anti-hyperglycemic activity in streptozotocin-induced rats. Preliminary phytochemical investigation revealed the presence of phenolic compounds and flavonoids which may be responcible for antidiabetic activity. Keywords: Solid lipid nanoparticles, Nateglinide, Cephalin, Diabetes, Stability studies
How to Cite
Nishant Verma, Dharmendra Kumar, Amrendra Kr Chaudhary, Ranjit Singh, & Sachin Tyagi. (1). ANTIDIABETIC POTENTIAL OF METHNOLIC BARK EXTRACT OF FICUS RELIGIOSA L. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. International Journal of Pharma Professional’s Research (IJPPR), 12(1), 1-4. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/218
Section
Articles
