ANTI INFLAMMATORY AND ANALGESIC POTENTIAL OF METHANOLIC EXTRACT OF LEPTADENIA PYROTECHNICA

Abstract

In the present study the anti-inflammatory and analgesic potential of methanolic extract of Leptadenia pyrotechnica was investigated. The methanolic extracts of Leptadenia pyrotechnica were ingested orally in the form of suspension in two different doses, 100 and 200 mg/kg body weight. The anti-inflammatory effect of Leptadenia pyrotechnica was observed in carragenan -induced paw oedema in wistar albino rats and formalininduced paw oedema in swiss albino mice and compared with the standard, indomethacin (5 mg/kg body weight). The analgesic effect was evaluated in swiss albino mice by Eddy’s hot plate method and compared with the standard, aspirin (25 mg/kg body weight). The methanolic extract of L. pyrotechnica produced significant reduction (p≤0.01) in inflammation i.e. 64.65 % (100 mg/kg body weight) and 76.75% (200 mg/kg body weight) as compared to the standard drug, indomethacin, which was 86.88%. The analgesic effects, produced a significant (p<0.01) reduction in the paw licking and jumping response for Leptadenia pyrotechnica (200 mg/kg) and aspirin (25 mg/kg) when compared to control. These results indicate that the extracts have analgesic and anti-inflammatory properties.