FORMULATION AND EVALUATION OF KETOROLAC TROMETHAMINE MICROPARTICLES FOR OCULAR DELIVERY

Abstract

The objective of the present work was to formulate and evaluate microparticles of Ketorolac tromethamine and produced sustained drug delivery for ocular delivery. In this 9 batches(A1-C3) of Ketorolac tromethamine microparticle was prepared with chitosan, Sodium Tri-polyphosphate and other ingredients by Ionotropic gelation technique. The prepared microparticles were evaluated for different parameters i.e % Drug yield, % Drug entrapment, Surface morphology, Zeta potential and in-vitro drug release for 24hrs in phosphate buffer 7.4 and simulated tear fluid. The best batch was performed stability studies for 6 months. The research concluded that Ketorolac tromethamine microparticles could be alternative for conventional dosage form.