DEVELOPMENT AND CHARACTERISATION OF ZOLMITRIPTAN THIOLATED CHITOSAN NANOPARTICLES

  • Sunena Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Techonolgy, Hisar (125001), Haryana (India).
  • Mishra DN Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Techonolgy, Hisar (125001), Haryana (India).
  • S.K.Singh Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Techonolgy, Hisar (125001), Haryana (India).
Keywords: Thiolation, Nanoparticles, Intranasal drug delivery, Migraine

Abstract

The present study was aimed to develop thiolated chitosan nanoparticles of Zolmitriptan for brain targeting in migraine via intranasal drug delivery. The thiolated chitosan was prepared using thiogycolic acid and chitosan in presence of catalyst and characterized using FTIR and DSC studies. Drug loaded nanoparticles were prepared by ionic gelation method using Sodium tripolyphosphate. The prepared NPs were characterized by FTIR spectroscopy and DSC techniques to confirm the drug loading without any chemical interactions between the drug and excipients. The morphology and size of the nanoparticles was affirmed using TEM analysis.
How to Cite
Sunena, Mishra DN, & S.K.Singh. (1). DEVELOPMENT AND CHARACTERISATION OF ZOLMITRIPTAN THIOLATED CHITOSAN NANOPARTICLES. International Journal of Pharma Professional’s Research (IJPPR), 7(2), 1-5. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/182
Issue
Vol 7 No 2 (2016): April Issue-2
Section
Articles