IN - VIVO STUDY ON INTERACTION OF KETOTIFEN FUMERATE WITH THEOPHYLINE ALONG WITH THEIR IR STUDIES

Abstract

This is very much important than any other time or ever to know about the medicines we take. If we take several different medicines, suffering from various types of diseases, consult more than one doctor or have certain health conditions, we and our doctors must be aware of all the medicines we take to avoid potential problems, such as drug interactions. The study of Drug interaction between various drugs has been conducted for many years and successful results have also been established. In the continuation of the study of drug interaction we have studied the in vivo interaction between the Kitotifen fumerate and Theophylline along with their IR studies. Invivo study showed decreased in the plasma concentration of free ketotifen fumarate when given concurrently with Theophylline which may be due to the drug interaction. IR study confirmed that there is an interaction between Ketotifen fumarate and Theophylline with the presence of extra peaks in their combination (aqueous extract 763.84 cm-1 , 1595.2 cm-1 , 2281.89 cm-1 ,2625.23 cm-1 , 2729.39 cm-1 ,3384.25 cm-1 & chloroform extract 703.08 cm-1 , 2115.04 cm-1 , 2161.33 cm-1 , 2232.7 cm-1 , 2657.06 cm-1 , 2701.42 cm-1 ) forms as compared to that of their pure forms. So, we can say that if both ketotifen fumerate with Theophylline administer concurrently, mild complex can be formed after reaction which can ultimately reduce the pharmacological activities of both combinations of drugs.