TECHNOLOGIES INFLUENCING RAPIDLY DISINTEGRATING DRUG DELIVERY SYSTEMS: A REVIEW

Abstract

Since the era of medicine has started every attempt has been made to facilitate the dose administration to the patient by achieving maximum efficacy. The evolution of rapidly disintegrating drug delivery systems had prove to be a milestone as they are designedto facilitate the administration of medication to patients who experience difficultyin swallowing (dysphagia) and for the convenience of all patients since the products may be administered at any time. Some tablets are also designed todissolve in saliva remarkably fast, within a few seconds,and are true fastdissolving tablets. Others contain agentsto enhance the rate of tablet disintegration in the oralcavity, and are more appropriately termed rapidly disintegratingtablets, as they may take up to a minute tocompletely disintegrate.A number of other rapidly disintegrating oral technologies have been introduced in recent years, such as Lyoc (Laboratoires L. Lafon, MaisonsAlfort, France), Orasolv(CIMA Labs, Inc., Eden Prairie, MN), WOWTAB (Yamanouchi Pharma Technologies, Inc., Palo Alto, CA), and Flashtab (Ethypharm). These technologies help pharmaceutical companies to extend the life cycle of their products and to differentiate them in themarketplace.Rapidly disintegrating drug delivery systems have significant advantages of both solid and liquid dosage forms.