CO-PROCESSING OF EXCIPIENTS: A REVIEW ON EXCIPIENT DEVELOPMENT FOR FAST DISSOLVING TABLET

Abstract

The Co-processing is the most widely explored method for the preparation of directly compressible adjuvants because it is cost effective and can be prepared in‐house based on the functionality required. This review article has been written with the aim of giving detailed information about the excipients, potential advantages of co-processed excipients, recent research on co-processed excipients for direct compression, various methods of preparing co-processed excipients for direct compression available in the market. Fast dissolving tablet have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms such as tablets, capsules, solutions and suspensions because of tremors of extremities and dysphasia. Recent development in fast dissolving technology mainly works to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the patented technologies available Apart from the conventional methods of fabrication, this review also provides the concept of some unique technologies like freeze drying, direct compression, spray drying, tablet molding, sublimation and evaluation of Fast dissolving tablet.