DEVELOPMENT AND EVALUATION OF TASTE MASKED FORMULATION OF OFLOXACIN & ORNIDAZOLE SUSPENSION.

Abstract

Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric and geriatric formulations is a challenge to the pharmacist in the present scenario.The major problem of these bothdrugswas very low solubility & bitter taste.So to solve both criteria taste masked suspension was made. The present work focus on bitter taste masking of OfloxacinOrnidazole.Batch method wasused for formation of drug resin complex. Various ion exchange resins such as Doshion P542, Doshion P514 and Indion 204weretried to obtained taste masked drug resin complex (DRC). About 18 trails were taken and On the basis of their data further optimization of batches were carried out. In order to ensure patient compliance bitterness masking becomes essential.Among all formulation F4 was considered best.