FORMULATION EVALUATION OF SUSTAINED RELEASE FLOATING BEADS OF METFORMIN HYDROCHLORIDE USING SODIUM ALGINATE

Abstract

The objective of this study was to prepare and characterize beads of Alginate for floating delivery of metformin hydrochloride (MH). The beads were evaluated for particle size, surface morphology, percent drug entrapment, percentage yield and in-vitro drug release. The formed beads were sufficiently hard and spherical in shape. Photomicrographs show that the surface was porous in nature. The average particle diameter of beads was found to be in the size range of 100-150 µm and percent entrapment was 66.7% to 88.8%. The beads demonstrated favorable in-vitro floating ability. Prepared formulations showed better controlled release behavior. It is concluded that beads of Alginate could be serve as an effective carrier for highly water-soluble anti-hyperglycaemic drugs like MH for the sustained release drug delivery.