FORMULATION AND EVALUATION OF TIMOLOL MALEATE OPTHALAMIC GEL FORMING SOLUTION WITH CARRAGENAN AND DIFFERENT PRESERVATIVE SYSTEM

Abstract

The aim of this study was to develop a gel forming solution with carrageenan polymer which can give prolonged effect and evaluate it for different parameters such as pH, viscosity, osmolality, gelling capacity, assay of preservative and Timolol maleate, presence of related substances, preservative efficacy, in-vitro release and drug release kinetic studies. The results obtained during the evaluation of Timolol maleate ophthalmic gel forming solution with carrageenan and different preservative systems are summarised below: The pH of all the formulations was determined and it was found within the specified limits and this cleared that the formulation will not cause any irritation in the eye. Viscosity of all the formulations was found suitable and in-vitro gelling capacity test was performed. Formulation with parabens (GF6) and formulation with SOC (GF3) showed good gelling capacity. Osmolality of all the formulations was determined by Osmometer instrument and it was found that all formulations possessed osmolality within the specified limits indicating that the formulations will not cause any discomfort upon instillation. From the available preservatives, parabens (combination of methyl paraben sodium and propyl paraben sodium), SOC and sodium perborate tetrahydrate were used because of their compatibility with the other formulation ingredients. Benzalkonium chloride and benzododecinum bromide were failed because they caused thread formation in the formulation.