FORMULATION AND OPTIMIZATION OF FLURBIPROFEN MATRIX TABLETS FOR COLONIC DRUG DELIVERY

Abstract

The present study is the development of colon targeted matrix tablets of the drug flurbiprofen,A Nsaids class of drug that is designed to for sustained effect.Different formulation( F1 TO F9 ) batches were made with the help of different polymers and their different proportions (Guar gum,Eudragit RL,Eudragit RS ) with the help of Wet granulation technique.The prepared matrix tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, invitro drug release.The in vitro release study had been done into simulated gastric and intestinal fluid with a new method. From this study we concluded that the batch F7 shows good results then the other batches.The batch F7 shows maximum prolong release upto 12 hrs.