EVALUATION OF THE WOUND HEALING ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MELIA AZEDARACH

Prashant Kumar; Raghuveer Irchhiaya; Rubina Lawrence; Amita Verma

Prashant Kumar Vaish Institute of Pharmaceutical Education & Research, Rohtak
Raghuveer Irchhiaya Dept.of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi.
Rubina Lawrence Dept. of Microbiology & Fermentation Technology, Sam Higginbottom Institute of Agriculture,Tech.& Sciences,Deemed to be University, Allahabad.
Amita Verma Dept. of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Tech. & Sciences,Deemed to be University,Allahabad.

Keywords: Melia azedarach, Excision wound model, Incision wounds model, epithelization time. Ethanolic extract. Povidone-iodine ointment.

Abstract

Being a rich heritage of medicinal plants in India there is always a hope for the valued medicinal plants for curing some of the untreated ailments. For the treatment of wounds no. of medicinal plants has been studied since yet. In the continuation of the same the present study is a step towards the healing of wounds by using the leaves of Melia azedarach. The efficacy of ethanolic extract of leaves of Melia azedarach evaluated in excision and incision wounds models and it was found that the extract showed marked effect in wound contraction, epithelization time in excision wound model and tensile strength in incision wound model with 5 % and 10% ointment of plant extract for 16 days. Povidone-iodine ointment (10%) was used as a standard and Student's t test was used for analyzing the data obtained from the study and the value of P < 0.05 and P<0.001 was considered to be significant. The effects obtained from ethanolic extract of Melia azedarach was compared with control and it was found significant.