A REVIEW ON EXTENDED RELEASE DOSAGE FORM OF NSAIDS USED IN COLON TARGETED DRUG DELIVERY

Abstract

The oral route plays an important role in the administration of drugs. It is considered to be most convenient for administration of drugs to patients. Oral administration of conventional dosage forms normally dissolves in the stomach fluid or intestinal fluid and absorb from these regions of the GIT depends upon the physicochemical properties of the drug, pharmaceutics factors and the patients related factors etc. It is a serious drawback in conditions where localized delivery of the drugs in the colon is required or in conditions where a drug needs to be protected from the hostile environment of upper GIT. Dosage forms that deliver drugs into the colon rather than upper GIT prefers number of advantages. Oral delivery of drugs to the colon is valuable in the treatment of diseases of colon (ulcerative colitis, Crohn's disease, carcinomas and infections) where by high local concentration can be achieved while minimizing side effects that occur because of release of drugs in the upper GIT or unnecessary systemic absorption.