DEVELOPMENT OF EXTENDED RELEASE DOSAGE FORM OF NSAIDS USED IN COLON TARGETED DRUG DELIVERY.

Abstract

In the present work, extended release matrix tablets of Diclofenac Sodium was formulated above its site of absorption.Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. The anti-inflammatory action effects of Diclofenac sodium are believed to be due to inhibition of both leukocyte migration and enzyme COX (COX-1&COX-2) leading to peripheral inhibition of prostaglandin synthesis. Antipyretic effect may be due to action in hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow and subsequent heat dissipation. Diclofenac sodium is a benzene acetic acid derivative, designated chemically as 2-[(2, 6-dichlorophenyl) amino] benzene acetic acid, monosodium salt. Formulation of Diclofenac sodium was formed by different techniques like direct compression and wet granulations having 100 mg strength