DESIGN, DEVELOPMENT AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM USING FAMOTIDINE FOR THE TREATMENT OF DUODENAL ULCER

Abstract

In the present work, floating gastro retentive formulation of Famotidine was formulated to sustained release of Famotidine above its site of absorption.Famotidine is histamine H2 receptor antagonist in treating gastric ulcer, duodenal ulcer, Zollinger Ellison syndrome, gastroesophegal reflux disease and erosive esophagitis. It inhibits acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. It competitively inhibits histamine action at all H2 receptors but their main clinical use is as inhibition of gastric acid secretion. It inhibited histamine stimulation and gastrin stimulated acid secretion. It decreases both basal and food stimulated acid secretion by 90% or more, but promote healing of duodenal ulcer. The swelling of the polymers used (HPMC K15M, Ethyl cellulose, Xanthan Gum) were determined by water uptake of the tablet. The percent swelling of the tablet was determined for 12 h at different time intervals. Increase in percent swelling was found with increasing concentration of polymers.