PREPARATION AND EVALUATION OF OXCARBAZEPINE FAST DISSOLVING TABLETS

Abstract

A fast dissolving tablet was prepared by using various super disintegrants like Polyplasdone XL10, Primojel, Ac-Di-Sol was taken in different concentration (10%, 12%, and 14%) and one control batch is prepared without disintegrants designated as four different groups of formulations(A,B,C and D) . Chemical incompatibility studies confirmed that there is no interaction between drug and excipients used in the formulations. All the batches are prepared by direct compression method. Effect of disintegrants on the disintegration behaviour was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the four groups, group (B) containing Ac-Di-Sol emerged as the best formulation and showed maximum dissolution rate.