Synthesis and antimicrobial evaluation of substituted benzoic acid-(5-oxo-pentylidene)-hydrazides

  • Balasubramanian Narasimhan Faculty of Pharmaceutical sciences, Maharshi Dayanand Univeristry, Rohtak, 124001
  • Muninder Faculty of Pharmaceutical sciences, Maharshi Dayanand Univeristry, Rohtak, 124001
  • Mahesh kumar Faculty of Pharmaceutical sciences, Maharshi Dayanand Univeristry, Rohtak, 124001
  • Pardeep Kumar Doon Valley Institute of Pharmacy and Medicine, Karnal, 132001
Keywords: Substituted benzoic acid derivatives; antimicrobial evaluation; Minimum inhibitory concentration

Abstract

A series of substituted benzoic acid-(5-oxo-pentylidene)-hydrazides were synthesized and studied for their antimicrobial activity. The synthesized compounds were characterized by physicochemical and spectral (IR and NMR) means. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and one Gram negative strains (Escherichia coli) and fungal strain Candida albicans and Aspergillus niger. Among the synthesized hydrazides 3,5-dinitro-bezoic acid-(5-oxo-pentylidene)-hydrazide (10) was found to be most effective antimicrobial agent. In general the synthesized compounds were found to be bacteriostatic and fungistatic in nature.
How to Cite
Balasubramanian Narasimhan, Muninder, Mahesh kumar, & Pardeep Kumar. (1). Synthesis and antimicrobial evaluation of substituted benzoic acid-(5-oxo-pentylidene)-hydrazides. International Journal of Pharma Professional’s Research (IJPPR), 6(1), 1181-1186. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/107
Issue
Vol 6 No 1 (2015): January Issue-1
Section
Articles