Development and Evaluation of Mouth Dissolving Tablets of Paracetamol

Abstract

Paracetamol is readily absorbed from gastrointestinal tract with peak plasma concentration occurring about 10 to 60 minutes after oral administration. It is distributed into most body tissues. Plasma protein binding is negligible at usual therapeutic doses but increase with increase doses. The elimination half life varies from 1 to 4 hours. The absorption process occurs by passive transport. The relative bioavailability ranges from 85 % to 98 %. The apparent volume of distribution of Acetaminophen is 0.95 L/kg. A small proportion 10 to 25 % of acetaminophen is bound to plasma protein and binding is increased in plasma concentration associated with overdose.The present study involved the preparation of mouth dissolving tablet of paracetamol. The tablets were prepared by wet granulation methods. We prepared batches (F1-F18) by wet granulation and studied their release kinetic. The formulations were studied for their mouth dissoving behaviour using simulated salivery fluid; the dissolution time was noted for each formulation. Lubricated blends were characterized for physical properties like loose bulk density, tapped density, angle of repose, Carr’s index, Hausner´s ratio; all blends showed satisfactory properties. Tablets were evaluated for uniformity of weight, thickness, hardness, percentage (%) friability and in vitro release studies.