Formulation and Evaluation of Nanogel Containing Quercetin for Treatment of Alopecia

Abstract

The study aimed to develop and characterize Quercetin-loaded nanogel formulations for enhanced drug delivery and therapeutic efficacy. Initially, nine formulation batches viz., F1-F9 of Quercetin nanoparticles were prepared and evaluated for key parameters including particle size & zeta potential, entrapment efficiency, surface morphology, in-vitro drug release and stability. FT-IR spectra confirmed the chemical integrity of Quercetin. Zeta potential values ranged from -5.45 mV to -17.65 mV, indicating good colloidal stability. Scanning Electron Microscopy (SEM) revealed spherical nanoparticles with a rough surface. In-vitro drug release studies demonstrated a release profile ranging from 74.12% to 95.32% over 12 hours, with the optimized batch (Fopt) achieving the highest release of 95.32%. Prepared nanoparticles were further converted into gel formulation. The pH, viscosity, and spreadability of the nanogel were within acceptable ranges, ensuring suitability for topical application. Stability studies confirmed the optimized formulation's physical integrity and sustained drug release under accelerated storage conditions. These findings suggest that Quercetin-loaded nanogels can provide a promising platform for efficient drug delivery with enhanced stability for treatment of Alopecia.