NEGATIVE REGULATION OF GLUCOSE UPTAKE BY COSTUS PICTUS LEAVES EXTRACT IN 3T3- L1 CELL LINE

  • Anup Kumar Maurya Department of Pharmaceutical Sciences, Shridhar University, Pilani, Rajasthan- 333031, India
  • Smriti Tripathi Department of Pharmaceutical Sciences, Shridhar University, Pilani, Rajasthan- 333031, India
  • Zabeer Ahmed Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu- 180001, India
  • Asha Bhagat Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu- 180001, India
Keywords: Diabetes, insulin, 3T3- L1 cell line, Costus pictus

Abstract

The leaf of Costus pictus is considered as an antidibetic in folklore medicine and is known to reduce the blood sugar, similar as insulin. The aim of the study is to investigate the effect of ethanolic extract of C. pictus leaf on glucose uptake by 3T3- L1 cell line (skeletal muscle cells) involved in glucose utilization. Ethanolic extract of C. pictus leaf was analyzed to study GLUT4 translocation and glucose uptake activity, but it has no direct peripheral action at 300 µg/ml dose comparable with insulin and metformin. The glucose uptake was not enhanced by the extract of C. pictus leaf.
How to Cite
Anup Kumar Maurya, Smriti Tripathi, Zabeer Ahmed, & Asha Bhagat. (1). NEGATIVE REGULATION OF GLUCOSE UPTAKE BY COSTUS PICTUS LEAVES EXTRACT IN 3T3- L1 CELL LINE. International Journal of Pharma Professional’s Research (IJPPR), 12(2), 1-4. Retrieved from https://ijppronline.com/index.php/IJPPR/article/view/216
Issue
Vol 12 No 2 (2021): April Issue-2
Section
Articles